Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis
Braz. j. infect. dis
;
22(2): 137-141, Mar.-Apr. 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-951630
ABSTRACT
ABSTRACT Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. GBS is a debilitating autoimmune disorder that affects peripheral nerves. Since ZIKV caused massive outbreaks in South America in the past few years, we aimed to systematically review the literature and perform a meta-analysis to estimate the prevalence of GBS among ZIKV-infected individuals. We searched PubMed and Cochrane databases and selected three studies for a meta-analysis. We estimated the prevalence of ZIKV-associated GBS to be 1.23% (95% CI = 1.17-1.29%). Limitations include paucity of data regarding previous flavivirus infections and ZIKV-infection confirmation issues. Our estimate seems to be low, but cannot be ignored, since ZIKV outbreaks affects an overwhelming number of individuals and GBS is a life-threatening debilitating condition, especially in pregnant women. ZIKV infection cases must be closely followed to assure prompt care to reduce the impact of GBS associated-sequelae on the quality of life of those affected.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Brotes de Enfermedades
/
Síndrome de Guillain-Barré
/
Virus Zika
/
Infección por el Virus Zika
Tipo de estudio:
Estudio de prevalencia
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Femenino
/
Humanos
/
Embarazo
País/Región como asunto:
America Central
/
America del Sur
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Italia
/
Reino Unido
Institución/País de afiliación:
King's College London/GB
/
Scientific Institute for Research, Hospitalization and Care/IT
/
Universidade Federal de Pernambuco/BR
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