Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux
Braz. j. med. biol. res
;
49(7): e5149, 2016. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-951688
ABSTRACT
The objective of this study was to perform a systematic review and meta-analysis to assess the effectiveness of proton pump inhibitors (PPI) for reflux disease in adult patients with laryngopharyngeal symptoms. A comprehensive search of Cochrane Library, EMBASE, Ovid EBM Reviews, and PubMed was performed for English-language literature about laryngopharyngeal reflux (LPR), in September 2014. The papers were filtered using pre-defined inclusion and exclusion criteria. Eight papers were identified and included in this meta-analysis. The sample comprised a pooled total of 370 patients, of which 210 and 160 patients took PPIs and placebo, respectively. The difference between PPIs and placebo groups in overall improvement of symptoms in adult patients with LPR was not statistically significant (RR=1.22; 95%CI=0.93-1.58; P=0.149). The difference in cough improvement was also not significant between PPIs and placebo groups (RR=0.65; 95%CI=0.30-1.41; P=0.279).
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
2-Piridinilmetilsulfinilbencimidazoles
/
Inhibidores de la Bomba de Protones
/
Reflujo Laringofaríngeo
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Estudio pronóstico
/
Revisiones Sistemáticas Evaluadas
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2016
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Shandong Province/CN
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