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Establishment of a rat model for uterine leiomyomas based on Western and traditional Chinese medicine theories
Zhao, Hui; Li, Yao; Xu, QiuXia; Peng, Fu; Zhao, JinShuang; Medical College of GeorgiaWebb, R. Clinton; Peng, Cheng; Yu, ChengHao.
  • Zhao, Hui; Chengdu University of Traditional Chinese Medicine. Chengdu. CN
  • Li, Yao; Chengdu University of Traditional Chinese Medicine. Chengdu. CN
  • Xu, QiuXia; Chengdu University of Traditional Chinese Medicine. Chengdu. CN
  • Peng, Fu; Chengdu University of Traditional Chinese Medicine. Chengdu. CN
  • Zhao, JinShuang; Chengdu University of Traditional Chinese Medicine. Chengdu. CN
  • Medical College of GeorgiaWebb, R. Clinton; Augusta University. Department of Physiology. Medical College of GeorgiaWebb, R. Clinton. Augusta. US
  • Peng, Cheng; Chengdu University of Traditional Chinese Medicine. Chengdu. CN
  • Yu, ChengHao; Chengdu University of Traditional Chinese Medicine. Chengdu. CN
Braz. j. med. biol. res ; 51(9): e7627, 2018. graf
Artículo en Inglés | LILACS | ID: biblio-951764
ABSTRACT
Uterine leiomyomas (ULs) are benign monoclonal tumors that arise from the underlying myometrial tissue in the uterus. Effective therapies are still lacking because of poor understanding of the pathophysiology and epidemiology. Hence, it is urgent to establish efficient animal models to screen novel anti-UL therapies. In this study, for the first time, traditional Chinese medicine and Western medicine were combined to establish an animal model of ULs in rats. In order to evaluate the function and value of the novel model, it was compared with other models. The long-term and short-term rat models for ULs were established using progesterone and diethylstilbestrol. Rats in Qi stagnation and blood stasis group were injected with epinephrine hydrochloride and received chronic unpredictable stress for two weeks. Rats in combining disease with syndrome group (CDWSG) received not only epinephrine hydrochloride injection and chronic unpredictable stress but also progesterone and diethylstilbestrol treatment. We analyzed differences in organ coefficient, uterus size, uterine pathology, concentrations of progesterone, estradiol, progesterone receptor, estrogen receptor, expression of desmin, α-smooth muscle actin, and vimentin among the five groups. The animal model of ULs was successfully constructed by loading the rats with estrogen and progesterone. The rat model of CDWSG was more stable than other groups and the method was the most efficient.
Asunto(s)


Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Uterinas / Modelos Animales de Enfermedad / Leiomioma / Medicina Tradicional China Tipo de estudio: Estudio diagnóstico Límite: Animales Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2018 Tipo del documento: Artículo País de afiliación: China / Estados Unidos Institución/País de afiliación: Augusta University/US / Chengdu University of Traditional Chinese Medicine/CN

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Neoplasias Uterinas / Modelos Animales de Enfermedad / Leiomioma / Medicina Tradicional China Tipo de estudio: Estudio diagnóstico Límite: Animales Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 2018 Tipo del documento: Artículo País de afiliación: China / Estados Unidos Institución/País de afiliación: Augusta University/US / Chengdu University of Traditional Chinese Medicine/CN