Marine drugs for cancer: surfacing biotechnological innovations from the oceans
Clinics
;
73(supl.1): e482s, 2018. graf
Artículo
en Inglés
| LILACS
| ID: biblio-952842
ABSTRACT
This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of these drugs has afforded valuable knowledge and crucial insights to meet the most common challenges in this endeavor, such as toxicity and supply. In this context, the development of these compounds will be discussed herein to illustrate, with successful examples provided by cytarabine, trabectedin, eribulin and brentuximab vedotin, the steps involved in this process as well as the scientific advances and technological innovation potential associated with developing a new drug from marine resources.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Biotecnología
/
Organismos Acuáticos
/
Desarrollo de Medicamentos
/
Neoplasias
/
Antineoplásicos
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Sao Paulo/BR
/
Universidade Federal do Ceara/BR
/
Universidade de Sao Paulo/BR
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