Epidemiology and biology of cutaneous human papillomavirus
Clinics
;
73(supl.1): e489s, 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-952844
ABSTRACT
Cutaneous human papillomaviruses (HPVs) include β- and γ-HPVs, in addition to a small fraction of α-HPVs. β-HPVs were first isolated from patients with the rare genetic disorder Epidermodysplasia verruciformis, and they are associated with the development of nonmelanoma skin cancer at sun-exposed skin sites in these individuals. Organ transplant recipients also have greater susceptibility to β-HPV infection of the skin and an increased risk of developing nonmelanoma skin cancer. In both immunosuppressed and immunocompromised individuals, cutaneous HPVs are ubiquitously disseminated throughout healthy skin and may be an intrinsic part of the commensal flora. Functional analysis of E6 and E7 proteins of specific cutaneous HPVs has provided a mechanistic comprehension of how these viruses may induce carcinogenesis. Nevertheless, additional research is crucial to better understand the pathological implications of the broad distribution of these HPVs.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Papillomaviridae
/
Neoplasias Cutáneas
/
Infecciones por Papillomavirus
Tipo de estudio:
Estudio de prevalencia
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de Sao Paulo/BR
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