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Interleukin 8 (-251 T>A) polymorphism in children and teenagers infected with Helicobacter pylori
Saes, Marina; Labio, Roger Willian de; Rasmussen, Lucas Trevizani; Payão, Spencer Luiz Marques.
  • Saes, Marina; Faculdade de Medicina de Marília. Marília. BR
  • Labio, Roger Willian de; Faculdade de Medicina de Marília. Marília. BR
  • Rasmussen, Lucas Trevizani; Universidade do Sagrado Coração. Bauru. BR
  • Payão, Spencer Luiz Marques; Faculdade de Medicina de Marília. Marília. BR
Artículo en Inglés | LILACS, VETINDEX | ID: biblio-954831
ABSTRACT
Background Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. This study evaluated the correlations between the -251 (T>A) (rs4073) polymorphism of interleukin-8 (IL-8), the etiology of gastric disease, and H. pylori infection in pediatric and adolescent patients. Methods DNA samples were obtained from 285 gastric biopsies from pediatric patients. H. pylori was detected by PCR, whereas PCR-RFLP was used to characterize the -251 (T>A) polymorphism of IL-8. Results The histological analysis revealed the presence of gastritis in 158 patients (55.44%). H. pylori was found in 71 samples (24.9%). The -251 (T>A) polymorphism revealed that 58 (29.47%) samples were TT, 143 (50.18%) samples were TA, and 84 (20.35%) samples were AA. Conclusions Our findings suggest that IL8-251 A allele may be an important risk factor for the development of gastric disease when associated with H. pylori infection.(AU)
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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Gastropatías / Polimorfismo de Longitud del Fragmento de Restricción / Factores de Riesgo / Interleucina-8 / Helicobacter pylori Tipo de estudio: Estudio de etiología / Factores de riesgo Idioma: Inglés Revista: J. venom. anim. toxins incl. trop. dis Año: 2017 Tipo del documento: Artículo Institución/País de afiliación: Faculdade de Medicina de Marília/BR / Universidade do Sagrado Coração/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Gastropatías / Polimorfismo de Longitud del Fragmento de Restricción / Factores de Riesgo / Interleucina-8 / Helicobacter pylori Tipo de estudio: Estudio de etiología / Factores de riesgo Idioma: Inglés Revista: J. venom. anim. toxins incl. trop. dis Año: 2017 Tipo del documento: Artículo Institución/País de afiliación: Faculdade de Medicina de Marília/BR / Universidade do Sagrado Coração/BR