Combatiendo el metabolismo de las células cancerosas mediante la activación de SIRT3 y el ejercicio físico / Combating tumor cells through SIRT3 activation and exercise
Rev. méd. Chile
;
146(6): 762-769, jun. 2018. graf
Artículo
en Español
| LILACS
| ID: biblio-961457
ABSTRACT
One of the main features of cancer is the high rate of cell proliferation and growth. To do this, cancer cells need to redirect their metabolism mainly towards anaerobic glycolysis and an increased mitochondrial glutamine energy metabolism. Sirtuins are cellular proteins with regulatory functions on metabolic pathways, genomic stability, apoptosis, longevity, inflammation, energy metabolism and oxidative stress. Sirtuins have emerged recently as a potential therapeutic option to treat several chronic diseases including cancer. This review summarizes the tumor suppressor function of Sirtuin 3 (SIRT3), highlighting its repressor effect on glycolytic metabolism, promoting mitochondrial metabolism and oxidative stress reduction. SIRT3 activation by exercise is particularly described since it may represent a potent tool for several types of cancer treatment.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Ejercicio Físico
/
Sirtuina 3
/
Neoplasias
Límite:
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de La Frontera/CL
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