Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report
São Paulo med. j
;
136(4): 361-367, July-Aug. 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-962733
ABSTRACT
ABSTRACT CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSIONS: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Cromosomas en Anillo
/
Leucemia Mieloide Aguda
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
São Paulo med. j
Asunto de la revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicina
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Alemania
Institución/País de afiliación:
Institute of Human Genetics/DE
/
Universidade do Estado do Rio de Janeiro (UERJ)/BR
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