Thalidomide administration inhibits the clinical evolution of the experimental autoimmune encephalomyelitis (eae) in lewis rats: preliminar results
Rev. interdisciplin. estud. exp. anim. hum. (impr.)
;
1(2): 58-61, Junho 2009. tab
Artículo
en Inglés
| LILACS
| ID: biblio-964323
ABSTRACT
Multiple sclerosis (MS) is a chronic neurodegenerative inflammatory disease of the central nervous system. Several immunomodulatory agents have been used to prevent MS acute exacerbations. Tumor Necrosis factor alpha (TNFα) and interferon gamma (IFN-γ) are two major inflammatory mediators. Recently, we investigated in our laboratory the therapeutic value of thalidomide, a recognized TNF-α inhibitor, for the treatment of MS using the classical Lewis rat model of experimental autoimmune encephalomyelitis ( EAE). The experimental study revealed that thalidomide reduces the incidence of EAE development in 90% of the cases. Hence we hypothesized that thalidomide may be an important therapeutical tool for prevention of acute exacerbations of the MS.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Talidomida
/
Esclerosis Múltiple Recurrente-Remitente
/
Encefalomielitis Autoinmune Experimental
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. interdisciplin. estud. exp. anim. hum. (impr.)
Asunto de la revista:
Biologia
Año:
2009
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Laboratory Analisys/BR
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