The rs878081 polymorphism of AIRE gene increases the risk of rheumatoid arthritis in a Chinese Han population: a case-control study
Braz. j. med. biol. res
;
51(12): e7944, 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-974256
ABSTRACT
The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. The rs878081 polymorphism of the AIRE gene was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, and stratification analysis. Genetic model analysis showed significant correlations between the TT genotype and the risk of RA (OR 1.89, 95%CI 1.03-3.47 in TT vs CC; OR 1.84, 95%CI 1.02-3.31 in TT vs CC+TC). Stratification analyses of sex, age, smoking, and alcoholism suggested that the rs878081 polymorphism of the AIRE gene increased RA risk among non-smokers. In conclusion, rs878081 polymorphism of AIRE gene increases the risk of RA in a Chinese Han population.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Artritis Reumatoide
/
Factores de Transcripción
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
China
Institución/País de afiliación:
Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University/CN
/
Second Affiliated Hospital of Jiaxing University/CN
/
Second Affiliated Hospital, Zhejiang University School of Medicine/CN
Similares
MEDLINE
...
LILACS
LIS