Protective effect of luteolin on the transgenic Drosophila model of Parkinson's disease
Braz. J. Pharm. Sci. (Online)
;
54(3): e17760, 2018. graf, ilus
Artículo
en Inglés
| LILACS
| ID: biblio-974401
ABSTRACT
In the present study we have studied the effect of 25, 50, 75 and 100 µM of luteolin on the transgenic Drosophila expressing human alpha synuclein. The doses of luteolin were established in diet and the PD flies were allowed to feed on it for 24 days. After 24 days of exposure the flies were assayed for climbing assay, oxidative stress markers, caspase-3 & 9 activity and dopamine content. The immunohistochemistry was also performed on the brain sections for the activity of tyrosine hydroxylase. The exposure of luteolin showed a dose dependent delay in the loss of climbing ability and activity, reduction in oxidative stress markers, caspase-3&9 activities and results in an increase in the dopamine content. The results obtained for the immunohistochemistry also supports the protective role of luteolin against the damage of the dopaminergic neurons
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Enfermedad de Parkinson
/
Luteolina
Idioma:
Inglés
Revista:
Braz. J. Pharm. Sci. (Online)
Asunto de la revista:
Farmacologia
/
Teraputica
/
Toxicologia
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
India
Institución/País de afiliación:
Aligarh Muslim University/IN
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