Oxidative stress: therapeutic approaches for cervical cancer treatment
Clinics
;
73(supl.1): e548s, 2018. graf
Artículo
en Inglés
| LILACS
| ID: biblio-974955
ABSTRACT
OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. In this context, oxidative stress, chronic inflammation and high-risk human papillomavirus can act in a synergistic manner. To counteract the harmful effects of oxidant species, protective molecules, known as antioxidant defenses, are produced by cells to maintain redox homeostasis. In recent years, the use of natural antioxidants as therapeutic strategies for cancer treatment has attracted the attention of the scientific community. This review discusses specific molecules and mechanisms that can act against or together with oxidative stress, presenting alternatives for cervical cancer prevention and treatment.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias del Cuello Uterino
/
Estrés Oxidativo
/
Antioxidantes
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Clinics
Asunto de la revista:
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Chile
Institución/País de afiliación:
Universidad de Chile/CL
/
Universidade de Sao Paulo/BR
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