Effect of topical ozonetherapy on gingival wound healing in pigs: histological and immuno-histochemical analysis
J. appl. oral sci
;
27: e20180015, 2019. graf
Artículo
en Inglés
| LILACS, BBO
| ID: biblio-975889
ABSTRACT
Abstract In this study, the effects of ozonetherapy on secondary wound healing were evaluated histologically and immuno-histochemically. Material and Methods:
8 healthy pigs were used in this study. Six wounds with 10 mm in diameter were created through the punch technique on the palatinal gingiva of each pig. Ozone gas was applied on only 3 wounds (test group) and the remaining 3 were left to natural healing (control group). Biopsy samples were taken from one of the wounds in each group on the third day, from another wound of each group on the seventh day, and from another one on the tenth day. Routine histological analysis and immuno-histochemical staining were performed to investigate transforming growth factor-beta (TGF-β) and (VEGF) expressions.Results:
No statistical difference was found between the test and control groups in terms of collagen fibers, epithelial formation and inflammation scores. A VEGF expression found in the test group was statistically higher than control group samples taken on the 3rd and 7th day. There was no statistical difference between the test and control groups in terms of TGF-β expression on any of the sampling days.Conclusion:
The topical application of ozone gas could be effective in the early stages of wound healing by increasing the amount of VEGF expression. Clinical Relevance Topical application of ozone gas may be effective in the early stages of oral wound healing.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Ozono
/
Cicatrización de Heridas
/
Encía
Límite:
Animales
Idioma:
Inglés
Revista:
J. appl. oral sci
Asunto de la revista:
Odontología
Año:
2019
Tipo del documento:
Artículo
País de afiliación:
Turquía
Institución/País de afiliación:
Biruni University/TR
/
Gazi University/TR
/
Hospital of Oral and Dental Health/TR
/
University of Health Sciences/TR
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