Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
Rev. bras. farmacogn
;
28(5): 564-567, Sept.-Oct. 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-977721
ABSTRACT
Abstract The chemical investigation of the n-hexane fraction of Salvadora persica L., Salvadoraceae, seeds afforded a new stearic acid ester, salvastearolide, together with five other phytosteroids identified as stigmasterol, β-sitosterol, Δ7-campesterol, Δ7-avenasterol and campesterol. Their structures were established on the basis of extensive spectroscopic methods including 1D and 2D NMR experiments and HRESI mass spectrometry. In addition, salvastearolide and the isolated fractions were tested for their cytotoxicity against human cancer cell lines MCF-7, MDA-MB-231 and HT-29. The n-hexane fraction exhibited significant anti-proliferative effect against human breast cancer cell line MCF-7 (IC50 50 µg/ml), while salvastearolide possessed a weak cytotoxic effect against MCF-7 cells with IC50 103.98 µg/ml.
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Índice:
LILACS (Américas)
Idioma:
Inglés
Revista:
Rev. bras. farmacogn
Asunto de la revista:
Farmacia
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Arabia Saudita
/
Corea del Sur
Institución/País de afiliación:
Jazan University/SA
/
King Abdulaziz University/SA
/
Kookmin University/KR
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