Association of angiotensin-converting enzyme insertion/deletion polymorphism with recurrent pregnancy loss: a meta-analysis of 26 case-control studies
Rev. bras. ginecol. obstet
;
40(10): 631-641, Oct. 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-977788
ABSTRACT
Abstract Objective Previous studies investigating the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and recurrent pregnancy loss (RPL) risk has provided inconsistent results. The aim of our study was to assess the association between the ACE I/D polymorphism and risk of RPL. Methods All studies published up to January 30, 2018 on the association of ACE I/D polymorphism with RPL were identified by searching the PubMed, Web of Knowledge, and Google scholar databases. Results A total of 26 case-control studies with 3,140 RPL cases and 3,370 controls were included in themeta-analysis. Overall, there was a significant association between ACE I/D polymorphism and RPL risk under the allele model (I versus D odds ratio [OR] = 0.538, 95% confidence interval [CI] = 0.451-0.643, p 0.001), the homozygote model (II versus DD OR = 0.766, 95% CI = 0.598-0.981, p = 0.035) and the recessive model (II versus ID + DD OR = 0.809, 95% CI = 0.658-0.994, p = 0.044). Subgroup analysis by ethnicity showed that there was a significant association between ACE I/D polymorphism and increased risk of RPL in Caucasian and West-Asian populations, but not in East-Asians. When stratified by number of recurrent miscarriages (RMs), a significant association between ACE I/D polymorphism and increased risk of RPL was detected in the group of studies with ≥ 2 RMs, but not in studies with ≥ 3 RMs. Conclusion Themeta-analysis suggests that ACE I/D polymorphism is associated with increased risk of RPL. The ACE I/D polymorphism may be a risk factor for RPL in Caucasian and West-Asian populations, but not in East-Asians.
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Índice:
LILACS (Américas)
Asunto principal:
Aborto Habitual
/
Peptidil-Dipeptidasa A
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Rev. bras. ginecol. obstet
Asunto de la revista:
Ginecologia
/
Obstetrícia
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Irán
Institución/País de afiliación:
Arak University of Medical Sciences/IR
/
Semnan University of Medical Sciences/IR
/
Shahid Sadoughi University of Medical Sciences/IR
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