Cost effectiveness of the cancer prevention program for carriers of the BRCA1/2 mutation
Rev. saúde pública (Online)
;
52: 94, 2018. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-979019
ABSTRACT
ABSTRACT OBJECTIVE: To analyze the cost effectiveness of the diagnostic program for the germline mutation in BRCA1/2 genes and of preventative strategies for the relatives of patients diagnosed with ovarian cancer associated with this mutation. METHODS: The study analyzed the cost effectiveness by developing an analysis of the Markov decision process from the perspective of the National Health System. The strategies compared reflect upon the adoption of genetic testing and preventative strategies for relatives or the usual care currently proposed. The incremental cost-effectiveness ratio was expressed in terms of cost per case avoided. The sensitivity analysis was performed in a univariate and deterministic manner. RESULTS: The study showed increments for effectiveness and for costs when performing genetic testing and adopting prophylactic measures for family members. The incremental cost-effectiveness ratio was estimated at R$908.58 per case of cancer avoided, a figure considered lower than the study's cost-effectiveness threshold (R$7,543.50). CONCLUSIONS: The program analyzed should be considered a cost-effective strategy for the national situation. Studies in various other countries have reached similar conclusions. One possible ramification of this research might the need to perform a budgetary-impact analysis of making the program one of the country's health policies.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Neoplasias Ováricas
/
Evaluación de Programas y Proyectos de Salud
/
Mutación de Línea Germinal
/
Genes BRCA1
/
Genes BRCA2
Tipo de estudio:
Estudio de etiología
/
Estudios de evaluación
/
Evaluación Económica en Salud
/
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Rev. saúde pública (Online)
Asunto de la revista:
Sa£de P£blica
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Países Bajos
Institución/País de afiliación:
Universidade de São Paulo/BR
/
University of Groningen/NL
Similares
MEDLINE
...
LILACS
LIS