Criptococosis cerebral, voriconazol, niveles plasmáticos y síndrome de reconstitución inmune: reporte de un caso / Cerebral cryptococcosis and immune reconstitution inflammatory syndrome: case report
Rev. méd. Chile
;
146(12): 1481-1485, dic. 2018. graf
Artículo
en Español
| LILACS
| ID: biblio-991360
ABSTRACT
We report a 45-year-old male with AIDS who had a Cryptococcus neoformans central nervous system infection. He was treated with amphotericin B deoxycholate subsequently changed to voriconazole due to systemic toxicity of the former. Plasma levels of voriconazole were insufficient with a standard dose (0.7 μg/mL), therefore, the dose was increased thereafter to reach appropriate levels (4.5 μg/mL). Anti-retroviral therapy was started five weeks after voriconazole initiation with non-interacting drugs and he was discharged after a favorable evolution. He was re-admitted three months later due to seizures; a brain magnetic resonance showed new sub-cortical nodules. After excluding alternative causes and demonstrating fungal eradication, an immune reconstitution inflammatory syndrome (IRIS) event was suspected and treated with a short course of steroids. His evolution was satisfactory.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Anfotericina B
/
Meningitis Criptocócica
/
Infecciones Oportunistas Relacionadas con el SIDA
/
Ácido Desoxicólico
/
Síndrome Inflamatorio de Reconstitución Inmune
/
Voriconazol
/
Antifúngicos
Límite:
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital Base de Valdivia/CL
/
Universidad Austral de Chile/CL
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