Splicing isoform-specific functional genomic in cancer cells
Appl. cancer res
;
38: 1-18, jan. 30, 2018. tab., ilus
Artículo
en Inglés
| LILACS, Inca
| ID: biblio-994739
ABSTRACT
Alternative splicing is a regulated process whereby one gene can generate multiple mRNA isoforms susceptible to be translated into protein isoforms of various functions. Several publications report the aberrant expression of splicing isoforms in cancer cells and tissues. However, in most cases, their function remains to be established. In this review article, I will discuss the molecular tool available to perform isoform-specific functional genomics, the methodologies to quantify their effectiveness and the resulting isoform-specific phenotype in human cancer cell lines (AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Carcinógenos
/
Isoformas de Proteínas
/
Genómica
/
Factores de Empalme de ARN
Límite:
Humanos
Idioma:
Inglés
Revista:
Appl. cancer res
Asunto de la revista:
Neoplasmas
Año:
2018
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
University of Texas Southwestern Medical/US
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