Anormalidades tiroideas en recién nacidos con sepsis neonatal temprana y tardia / Thyroid abnormalities in newborns with early and late neonatal sepsis

ABSTRACT

Purpose: To evaluate thyroid function in newborns with early and late neonatal sepsis by measuring T3, T4, TSH. Methods: The study included 80 newborns with a diagnosis of neonatal sepsis divided into two groups early neonatal sepsis and late neonatal sepsis, which during the clinical and laboratory manifestations of sepsis showed changes in thyroid hormones, particularly low T3 syndrome and T3-T4 low syndrome. We excluded newborns children of mothers with disease with thyroid disease, those with a history of perinatal asphyxia, congenital malformations and major surgeries. Results: The development of the non-thyroid disease syndrome was confirmed in the two study groups with a prevalence of 54.2% for neonates with early neonatal sepsis and 80.95% for neonates with late neonatal sepsis, the most frequent being the low T3 in neonates with early neonatal sepsis and low T4 syndrome in neonates with late sepsis. These findings are relevant since there is evidence that low levels of thyroid hormones are associated with a worse prognosis and a poor evolution in severely ill neonates Conclusions: The syndrome of non-thyroid disease is frequent in neonates with neonatal sepsis, although it manifests itself with variable patterns according to the type of neonatal sepsis. Larger studies are needed to evaluate in greater depth the prognostic value of the syndrome in critical neonates