Structural Assessment of Chemical Constituent of Sidaguri (Sida rhombifolia Linn) and Its Ability to Inhibit Cyclooxygenase
Pesqui. bras. odontopediatria clín. integr
;
19(1): 4773, 01 Fevereiro 2019. tab, graf
Artículo
en Inglés
| LILACS, BBO
| ID: biblio-998267
ABSTRACT
Objective:
To elicit the structure of isolated compounds from roots of sidaguri (Sida rhombifolia Linn). Material andMethods:
Several organic standard protocols were involved, including extraction, fractionation, and phytochemical testing. Further spectroscopy methods, FTIR and 1HNMR, were used to determine the predicted structure of molecules, while their ability to inhibit cyclooxygenase (COX 1 and 2) were tested using in vitro method.Results:
Overall assessments showed that the structure of the sidaguri is a long chain aliphatic carboxylic acid and identified as Z-3, 6, 6 trimethylhept-2-en-1-ol (T12) and nonanoic (T13). Both isolates significantly inhibit COX-1 and COX-2 non-selectively (the COX-1/COX-2 ratio for T12 was 0.91 and 0.82; while COX-1/COX-2 ratio for T13 was 0.89 and 0.87 at concentrations of 0.05 and 0.025 µg/mL respectively).Conclusion:
The active compounds of Sidaguri have antiinflammatory effect by inhibiting COX non-selectively.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Análisis Espectral
/
Ciclooxigenasa 1
/
Ciclooxigenasa 2
/
Antiinflamatorios
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Pesqui. bras. odontopediatria clín. integr
Asunto de la revista:
Odontología
Año:
2019
Tipo del documento:
Artículo
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