Disposition kinetics of ciprofloxacin after different oral dosage level in rabbits

ABSTRACT

Ciprofloxacin a flouroquinolone antibacterial drug was orally administered to healthy white albino rabbits [n=12] a single dose of 10, 20, and 30 mg/Kg body weight using a randomized crossover design. Plasma samples were collected at various times over 12 hours following drug administration. The drugs were detected by high performance liquid chromatography [HPLC], and plasma drug concentration versus time curve were subjected to non-compartment and two compartment pharmacokinetic analysis. Descriptive statistics were determined for each doses, and comparison were made among doses groups for selected pharmacokinetic parameters. Result indicated that increasing dose of ciprofloxacin resulted in increased plasma concentration. Maximum concentration [C max] was 0.43 + 0.007, 0.84 +/- 0.01, and 1.46+ 0.013 micro gm/ml for the doses of 10, 20, and 30mg/kg body weight. AUC[0-t], AUC[0-00] and MRT were significantly greater at 30mg/kg and showed significant difference with doses [P<0.05], where as other parameters like absorption rate constant, distribution rate constant and elimination rate constant did not show significant difference