Caffeic acid phenethyl ester decreases the level of S-100B protin after middle cerebral after occlusion in rabbits

ABSTRACT

Effects of caffeic acid phenethyl ester [CAPE] on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery [MCA] occlusion in rabbits. Twenty rabbits were divided into four groups [n=5] control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10microg/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent