Suspected cardiotoxicity of clarithromycin in critically ill patients
Anaesthesia, Pain and Intensive Care. 2009; 13 (1): 28-30
en Inglés
| IMEMR
| ID: emr-101182
ABSTRACT
Clarithromycin, a macrolide antibiotic is known to have an arrhythmogenic potential in the presence of comparable QT prolongation. Indeed, the extent of QT prolongation has been used as a surrogate marker for cardiotoxicity and sudden cardiac death. We report a case series of three adult patients who were transferred to our intensive care unit [ICU] at Peradeniya Teaching Hospital, Peradeniya [Sri Lanka], and needed inotropic support and mechanical ventilation. All the three of them were treated with a standard dose regimen of intravenous clarithromycin for suspected atypical pneumonia, after which they dramatically deteriorated and unexpectedly died within 72 hours. In the absence of other known precipitating factors, cardiotoxicity of clarithromycin was suspected as the main causative factor for these deaths
Buscar en Google
Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Neumonía
/
Literatura de Revisión como Asunto
/
Torsades de Pointes
/
Enfermedad Crítica
/
Taquicardia Ventricular
/
Electrocardiografía
/
Cardiotoxinas
/
Unidades de Cuidados Intensivos
Tipo de estudio:
Informe de Casos
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Anaesth. Pain Intensive Care
Año:
2009
Similares
MEDLINE
...
LILACS
LIS