Microbial response to steroids

ABSTRACT

The metabolic activities of Aspergillus nidulans culture able to oxygenate progesterone [P] at C-6 beta; 11 alpha and 21-positions, responded differently to the added P. Thus, a rapid sugar and a limited nitrogen uptakes leading to the accumulation of lipid materials was recorded in the presence of P. Similarly, the detailed analysis of nucleic acids, amino acids, fatty acids and sterol constituents revealed different profiles when P was supplemented to the fermentation medium