Ion-exchange, an approach to prepare an oral floating drug delivery system for diclofenac
IJPR-Iranian Journal of Pharmaceutical Research. 2004; 3 (2): 93-97
en Inglés
| IMEMR
| ID: emr-102859
ABSTRACT
Using ion-exchange resins, a multiple-unit type of oral floating dosage system has been prepared to prolong gastric emptying time of dosage form. The system is composed of beads of drug-resin complex, which are loaded with bicarbonate ions and coated with a hydrophobic polymer. The system is so designed that when the beads reach the stomach, chloride ions are exchanged with bicarbonate and drug ions. The generated CO[2] is entrapped in the polymeric coated resins and causes the beads to float. In this study, Amberlite-IRA 900 was loaded with diclofenac and bicarbonate ions, using a batch method. The beads were encapsulated with a hydrophobic polymer [ethyl cellulose or Eudragit RS-100]. To find an appropriate formulation, the factors affecting the drug loading, floating ability and drug release were investigated. Based on the result obtained, maximum loading efficiency was attained at 3 h, using an aqueous diclofenac solution and resin beads measuring 430 m in diameter. Drug release from both uncoated complexes of diclofenac-resin, and diclofenac-bicarbonate-resin occurred via particle-diffusion. The ethyl cellulose-coated beads have a desirable floating capability in comparison with the Eudragit RS-100 coated beads on HC1 0.1M solution containing 0.02% polysorbate 80
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Dióxido de Carbono
/
Celulosa
/
Diclofenaco
/
Sistemas de Liberación de Medicamentos
/
Bicarbonato de Sodio
Idioma:
Inglés
Revista:
Iran. J. Pharm. Res.
Año:
2004
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