JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2008; 18 (7): 451-457
en Inglés
| IMEMR
| ID: emr-102890
ABSTRACT
Hepatitis B Virus [HBV] leads to a number of hepatic complications, from acute to chronic hepatitis, cirrhosis and hepatocellular carcinoma, is a well-established fact. Upcoming clinical research, over the years, associates numerous extrahepatic manifestations during the acute and chronic episodes of hepatitis B with significant morbidity and mortality. A causal relationship between HBV and serious autoimmune disorders has also been observed among certain susceptible vaccine recipients in a defined temporal period following immunization. The cause of these extrahepatic manifestations is generally believed to be immune mediated. The most commonly described include skin rash, arthritis, arthralgia, glomerulonephritis, polyarteritis nodosa, and papular acrodermatitis etc. The serum-sickness like "arthritis-dermatitis" prodrome has also been observed in approximately one-third of patients acquiring HBV infections. Skin manifestations of HBV infection typically present as palpable purpura reported to be caused by chronic HBV, although this association remains controversial. To consider the relationship between HBV and other clinically significant disorders as well as serious autoimmune disorders among certain vaccine recipients is the topic of this review. Variable factors that influence extrahepatic manifestation are discussed, including possible synergy between hepatitis B virus and the immune system
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Poliarteritis Nudosa
/
Polimialgia Reumática
/
Artritis
/
Enfermedad del Suero
/
Enfermedades de la Piel
/
Enfermedades Autoinmunes
/
Vacunas contra Hepatitis B
/
Glomerulonefritis
/
Hepatitis B
/
Inmunidad Celular
Límite:
Humanos
Idioma:
Inglés
Revista:
J. Coll. Physicians Surg. Pak.
Año:
2008
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