Frequency of HCV infection and its genotypes among patients attending a liver clinic and voluntary blood donors in a rural area of Pakistan
Pakistan Journal of Medical Sciences. 2009; 25 (4): 579-582
en Inglés
| IMEMR
| ID: emr-103369
ABSTRACT
To determine the frequency of Hepatitis C virus [HCV] infection and its genotypic distribution in a rural area of Sindh, Pakistan. Retrospective study of patients attending the Free Liver Clinic [FLC], and investigated for detectable HCV antibodies [n=1638], and those screened for HCV infection prior to voluntary blood donation [n=804] at a teaching hospital, located in rural Sindh. All patients had HCV antibodies tested by ELISA. A total of 1022 patients, who tested 'reactive' to HCV antibodies, and who could financially afford to have HCV RNA tested by PCR, had their results analysed. A total of 200 patients also had their HCV genotyped and analysed. Patients at FLC had a higher chance of being reactive for HCV antibodies, compared to voluntary blood donors [20% VS 14% - p = 0.004]. HCV RNA was detectable in 904/1022 [88%] patients. Among typeable genotypes, 125/166 [75%] had a single genotype, and 7 patients [4%] were infected with genotype 1, either alone [n=4] or in combination with 3a. One out of every five people tested in our FLC, and 14% of "healthy" voluntary blood donors were seropositive for HCV antibodies. Genotype 1 is very rare in our region
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Población Rural
/
Donantes de Sangre
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Ensayo de Inmunoadsorción Enzimática
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Reacción en Cadena de la Polimerasa
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Estudios Retrospectivos
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Anticuerpos contra la Hepatitis C
/
Genotipo
/
Hígado
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Pak. J. Med. Sci.
Año:
2009
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