[Development of different formulae of sustained release metoclopramide suppositories and studying their in -vitro drug release]

ABSTRACT

Sustained release suppositories are new preparations, which may relief the patient form applying suppositories many times per a day. Metoclopramide hydrochloride is one of the commonly used medicaments, which are good candidates to be formulated as controlled release suppository, as it has short half life. The suppositories were manufactured using fusion method. The drug release profiles from these suppositories were monitored using dissolution tester. It was found that suppositories formulated form the mixture PEG / Ethyl cellulose [6535 ww] released Metoclopramide hydrochloride slowly, as its release time lasted for a period of time of 26 hours. Moreover, the mechanical properties of these suppositories were acceptable