[Comparison of serum CA-125 level in ruptured and unruptured tubal pregnancies in Yazd/Iran during 2001-2006]

ABSTRACT

This study aimed to determine if serial measurement of serum CA-125 level could be used as a useful test in the differential diagnosis of intact and ruptured tubal pregnancies. In a single-blind prospective controlled clinical study, 59 women with tubal pregnancy of 6-12 weeks [26 women with ruptured tubal pregnancy, 33 women with intact tubal pregnancy and 59 women with normal intrauterine pregnancy of the same gestational age as control group] were studied prospectively. Serum CA-125 levels were measured in all women and compared among three groups. Demographic features [age, gestational age, parity and educational level] were not significantly different in three groups. CA-125 level in ruptured tubal pregnancy group was significantly higher than that in control group [P = 0.04]. Both these two groups had higher levels of CA-125 comparing to the intact tubal pregnancy group [P = 0.001, P = 0.006, respectively]. In intact tubal pregnancies managed with medical treatment, serial measurements of CA-125 could be a supplementary test for an early diagnosis of tubal rupture