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p53 protein accumulation and presence of visceral metastasis are independent prognostic factors for survival in patients with metastatic inflammatory breast carcinoma
Medical Principles and Practice. 2011; 20 (2): 159-164
en Inglés | IMEMR | ID: emr-104195
ABSTRACT
The aim of this study was to determine the markers of prognosis in metastatic inflammatory breast cancer [IBC]. The prognostic value of patients' clinical characteristics and expression of c-erbB-2, p53, Ki-67, ER and PgR were assessed in the 45 patients with IBC who had developed distant metastasis. Immunohisto-chemical methods were used to detect the expression of c-erbB-2, p53, Ki-67, ER and PgR in surgical resection specimens of the patients' primary tumor. The median overall survival [OS] measured from the diagnosis of metastatic disease was 23 months. In the univariate analysis, p53 protein accumulation and the presence of visceral metastasis were predictive of poor survival [p = 0.01 and 0.003, respectively]. In the multivariate analysis, accumulation of p53 protein and the presence of visceral metastasis correlated with OS [p = 0.02 and 0.008, respectively]. In metastatic IBC, accumulation of p53 protein and presence of visceral metastasis are independent prognostic factors for OS. Established prognostic factors in non-IBC patients such as patient age, histologic grade, hormone receptor status and c-erbB-2 status did not have independent significance in IBC in this Study
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Índice: IMEMR (Mediterraneo Oriental) Idioma: Inglés Revista: Med. Princ. Pract. Año: 2011

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Índice: IMEMR (Mediterraneo Oriental) Idioma: Inglés Revista: Med. Princ. Pract. Año: 2011