Inflammatory markers [interleukin-6 and C- reactive proteins] in patients with type 2 diabetes mellitus and positive family history of ischemic heart disease

ABSTRACT

Patients with family history of type-2 diabetes and ischemic heart disease [IHD] have an increased risk of developing these diseases in the future. It's currently believed that inflammatory mediators such as Interleukin-6 [IL-6] and C-reactive protein [CRP] play an important role in the pathogenesis of metabolic disorders. This study was conducted to assess the parameters of chronic inflammation in patients with newly diagnosed diabetes and positive family history of ischemic heart disease. The present study included 48 Iraqi patients with a diagnosis of diabetes established since 2003 using the 1999 WHO criteria, 20"of these patients had a family history of ischemic heart disease. The mean age of study participants was 49.4 +/- 10.2 years [ranging from 20 - 68]. Enzyme linked immunosorbant assay [ELISA] used to detect IL-6 and CRP,. while blood sugar and lipid profile were detected using commercially available kits which provided by [BioRad]. It was found that patients with a positive family history of IHD the concentration of IL 6 and CRP were found to be higher while HDL were found to be lower when compared with type 2 diabetic subjects with a negative family history for IHD. This finding demo nstrated that patients with newly diagnosed diabetes and a family history of IHD have increased risk of macroangiopathic complications related to the elevated concentrations of inflammatory markers