[Genetic basis parkinson disease]

ABSTRACT

In the past decade, six monogenic forms of Parkinson disease have been diagnosed. Identification of these genes, has revolutionized the previous view of neorogenetic etiology of Parkinson disease. The most prevalent genes are LRRK2 and PARKIN. The main focus of recent researches is understanding the function of these genes and involved proteins in hereditary Parkinson disease, which helps better understanding of pathophysiologyic mechanisms involved in Parkinson disease. Unfortunately genetic tests for Parkinson disease are too expensive and don't predict the course of disease and also don't palsy significant role in family planning .There is no neuroprotective treatment for PD, so genetic tests don't affect PD treatment. However, genetic tests are useful for diagnosing at risk groups and also better understanding preclinical changes and compensatory mechanisms, which are useful for discovery of neuroprotective drugs and strategies