study of plasma leptin as a risk factor for ischemic heart disease

ABSTRACT

Leptin which is peptide hormone secreted by adipose tissue was known to regulate body weight and adipose tissue mass through a feedback mechanism. Circulating leptin levels refect the net amount of adipose tissue for a given individual, being elevated in obese subjects and reduced in under weight subjects. This study was conducted on 87 subjects. Allocated in 5 study groups Group l 19 patients [l2male and 7 female] .IHD with D.M. Group Il 19 patients [11 male and 8 female] IHD with hypertension Group Ill 14 patients [all are male] IHD with smoking. Group IV 15 patients [9 male and 6 female] IHD without risk factor. Group V contained 20 healthy subjects [I 2male and 8 female] as controls. Lipid profile, serum insulin, serum leptin and BMI was estimated to all subjects. The present study showed that serum insulin level was significantly increased in diabetic patient with IHD as compared to controls, but did not changed significantly with other IHD groups as compared to controls. Serum leptin was significantly increased in all IHD] except diabetic patients as compared to controls. However serum leptin not significantly differ in IHD patients without risk factors as compared with IHD patients with risk factors. No statistically significant difference existed between male and female IHD patients regarding of serum leptin and BMI. Also, the present study showed that significant positive correlation between serum leptin and serum insulin levels in IHD patients with D.M. and non significant correlation in IHD patients with hypertension, smoking and lHD without risk factor, Also, our results showd that non significant correlation between serum leptin and BMI in IHD diabetic patients, but significant positive correlation in IHD with hypertension. There is significant negative correlation between serum leptin and HDLc in lHD patients without risk factors. Leptin which is peptide hormone secreted by adipose tissue was considered as a risk factor for IHD. The mechanism by which leptin can cause IHD are still not definitely established