Impact of tissue typing matching on early graft function

ABSTRACT

Our study was conducted in Nasser institute. 60 patients were included in the study. They -were on regular hemodialysis and underwent kidney transplantation [46 males and 14 females], with a mean age of [32.03 +/- 10.57] years. 17 cases had related living donors and 43 cases had unrelated living donors. Patients were followed for six months. There was non significant relationship [P>0.05] between Zero match, one mismatch out of 6, two mismatches out of 6 [of HLA-A, HLA-B and HLA-DR] and the survival of the graft. Also there was only significant difference between acutely rejected grafts and non-rejected grafts [P<0.05], with only one successful match out of 6, being having even more successful matches out of 6 but didn't have significant effect on survival of the graft. Having more than one halotype or less, in common between donor and recipient at tissue matching didn't differ much on outcome of the graft [P>0.05]- Being related or unrelated donors, gender of donors and recipients and blood grouping didn't affect much the outcome of the graft [P>0.05]. Cases with more than 1 successful match out of 6 had significant difference in serum creatinine between rejected and non rejected grafts