Lithium clearance and sodium lithium counter transport in insulin dependent diabetes mellitus

ABSTRACT

Our study was conducted on 24 insulin dependent diabetic patients in comparison to 10 normal healthy control subjects. the group of the patients were classified according to the results obtained into 3 groups. The list was eight diabetic patients without nephropathy, the second was eight diabetic patients with nephropathy and the third was eight diabetic hypertensive patients, Both diabetics and control were subjected to full clinical examination and laboratory investigations [plasma lithium, lithium clearance, fractional Iithium clearance [FcLi] and sodium-lithium counter transport [Na [+] /Li [+] CT]. The results showed mild elevation of serum sodium in IDDM groups compared to control. FcLi showed a highly reduction in IDDM groups compared to control group. Na [+] /Li [+] CT showed a statistically significant elevation in IDDM groups compared to control group