Intensive insulin therapy versus conventional insulin therapy for critically ill trauma patients admitted to ICU

ABSTRACT

The objective of our study was to evaluate the beneficial effect of IIT in reducing mortality and morbidity in critically ill trauma patients admitted to ICU. Nested cohort study within a Randomized Controlled Trial. All trauma patients with GCS mortality. There was no difference in ICU mortality between IIT and CIT groups [6.5% vs. 5.5%, p=0.67]. After adjustment for baseline characteristics, IIT therapy was also not associated with mortality [Adjusted Hazard Ratio 1.33, 95% CI 0.35-5.05]. IIT therapy was associated with a significant increase in the incidence of hypoglycemia as compared to CIT, at least one hypoglycemia episode occurred in 18.5% of patients in IIT and 1.3% in the CIT group [P<0.0001]. IIT was not associated with survival improvement in trauma patients admitted to ICU and was associated with increased incidence of hypoglycemia