Phenotypic and genotypic profile in Egyptian non-Hodgkin's lymphoma

ABSTRACT

All the cases of well differentiated lymphocytic neoplasm showed double arrangement along IgH and TCR "beta" genes. These immunogenetic data suggested that B cell well differentiated lymphocytic neoplasms are relatively homogeneous disorder. This double rearrangement was found to be 100% in grade I, 20% in grade II and 22% in grade III. This decrease in the frequency of double rearrangement along the line of differentiation may support the view point that small cell NHL arise from immature group and as the cell differentiates, commitment to the corresponding cell line is more and more achieved