In vivo radiosensitization of nitroimidazole derivative [KIN-804] compared with misonidazole [MISO]

ABSTRACT

The effects of a single dose of KIN-804 and MISO on liver and Ehrlich solid carcinoma [ESC] have been studied in Swiss albino mice. KIN-804 and MISO were administered at doses of 800 and 400 mg/Kg body weight, respectively. Liver glucose-6-phosphatase [G-6-pase], glutathione content and superoxide dismutase of ESC, were measured at different times from drug administration. [G-6-pase] was elevated significantly 24 hours after MISO only, while GSH and SOD showed nearly the same changes after MISO and KIN 804. Therefore, KIN-804 is a less toxic radiosensitizer and should be implicated in clinical trials