Enzymatic changes in the gingival tissues after radiotherapy

ABSTRACT

Twelve subjects with radiosensitive malignancies in the head and neck and 12 control normal patients with healthy gingival tissues are included in this study. A single specimen was taken from the gingiva of control patients, while 3 specimens where taken from the radiotherapy patients [before, after, and 6 months later radiotherapy]. Lypholisation of the tissues was done and Apizym kit was used. The results showed significant biochemical changes in the enzymatic activities of the gingival tissues after radiotherapy. A difference is quite apparent between control and radiotherapy group, for all enzymes except for estraselipase and B-galactosidase. These changes are expected to participate significantly in the histopathochemical and clinical changes in the role tissue after radiotherapy