Safety and efficacy of pegylated interferon alfa-2a for the treatment of hepatitis c in patients with major thalassemia
IJBC-Iranian Journal of blood and Cancer. 2009; 1 (4): 129-137
en Inglés
| IMEMR
| ID: emr-106563
ABSTRACT
Hepatitis C virus [HCV] infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. In this study we aimed to evaluate the effects of pegylated interferon alfa-2a [PEG-IFN A-2a] in reducing serum ALT and eradicating serum hepatitis C virus [HCV] RNA in HCV infected polytransfused thalassemic patients. A cohort of 51 HCV-RNA positive thalassemic patients were enrolled to our study and received 180 u,g PEG-IFN A-2a once-weekly for 48 weeks. The primary end point was sustained virological response [SVR]. The secondary outcome was normalization of ALT. Patient safety was assured by monthly, and if needed, weekly laboratory assessment and visits. Of 52 patients, 42 participants completed the treatment schedule. A sustained virological response [SVR] was attained in 22/51 [43%] cases. Among non-responders or relapsers to previous HCV antiviral therapy, 9/27 [33%] attained an SVR. Five patients died during treatment and 3 subjects discontinued the therapy because of adverse effects. Adverse events were generally mild, and laboratory abnormalities were rare. A course of 48-week PEG-IFN A-2a monotherapy is effective in eradicating HCV-RNA during treatment. But about one third of thalassemic patients would relapse within 6 months of treatment schedule completion, in whom combination therapy is needed
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Polietilenglicoles
/
Estudios Prospectivos
/
Estudios de Cohortes
/
Resultado del Tratamiento
/
Hepatitis C
/
Talasemia beta
Tipo de estudio:
Estudio de incidencia
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Iran. J. blood Cancer
Año:
2009
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