Effect of the anti-oestrogen tamoxifen on some bile constituents in the dog

ABSTRACT

The effect of oral administration of tamoxifen in a dose of 0.3 mg/kg daily for 3 months was investigated on some constituents of hepatic bile, gallbladder bile and serum of mongrel dogs. Tamoxifen caused significant increase in the level of total cholesterol, triglycerides, alkaline phosphatase and bilirubin in bile and serum. Total protein concentration did not change significantly in both bile and serum. Also, serum albumin did not alter, while albumin/globulin ratio significantly decreased. Osmolality and sodium increased in bile while potassium level decreased. No changes were observed in serum osmolality, sodium or potassium levels. These results support the concept that tamoxifen has some estrogen-like effects