Effects of immunological modulations induced by schistosoma mansoni or echinostome caproni on trichinella spinals infection

ABSTRACT

The present study revealed the effects of E. caproni [group I] and S. mansoni [group II] primary infection on Tr. spiralis challenge in Swiss albino mice. The immunological studies included splenocyte antibody forming capacities [PFC], specific antibody titer against Tr. spiralis larvae, neutrophil phagocytic activity and serum levels of circulating immune complexes. The data was compared with normal and single Tr. spiralis infected controls. The immunosuppressive effect of Tr. spiralis infection on PFC was augmented by S. mansoni [group II] while E. caproni [group I] had enhanced it due to the stimulatory effect of the immunological parameters of E. caproni. E. caproni and S. mansoni primary infection had produced significant decrease of both worm and larval counts of Tr. spiralis challenge, this may be due to sharing common antigens. These results were parallel to histopathological picture of small intestine, mesenteric lymph nodes and spleen of the experimental groups