Protective effect of vitamin E on chronic liver damage induced by carbon-tetrachloride [ccl4] in rats

ABSTRACT

The objective of this study was undertaken to determine whether a sustained increase in hepatic vitamin E could prevent or reduce the extent of CCl4-induced chronic-liver damage and the cirrhotic process. Free radicals affect virtually all aspects of biological existence by reaction and modification of structural, metabolic and genetic material. Studies were performed to examine the mechanisms for the protective effect of free radicals scavengers and to investigate whether the oxidative damage produced in the liver exposed to CCl4 in rats and to find out the effect of antioxidant vitamin E and its ability to protect cell membrane from lipid peroxidation mediated damage and its synthetic derivatives is able to prevent the onset of cell damage consequent to the induction of oxidative stress in different systems in vitro and in experimental acute intoxication with CCl4. 4 groups of male albino rats were studied. The first served as control, the second was fed vitamin E supplemented diet, the third was treated with CCl4 and the last group was treated with CCl4 and after that was supplemented with vitamin E diet