Some biochemical alterations as influenced by hyperviataminosis D3

ABSTRACT

The effect of daily administration of vitamin D3 indifferent doses [500, 1000, 5.000, 10.000, 20.000, 50.000 and 100.000 I.U/Kg b.wt.] on serum calcium [Ca], calcium bound protein [Ca BP], inorganic phosphorus [IP], lipoproteins and protein fractions was studied for 4 weeks in albino rats. The data revealed a marked elevation in serum Ca, Ca Bp and IP and a significant increase in beta-lipoprotein. Hypoalbuminemia and subsequent decrease in A/G ratio was observed. A marked increase in y-globulin was found with low doses of vitamin D3. A reversed pattern occurred when high doses of vitamin D3 were given. These results confirmed the harmful effect of hypervitaminosis D3