Effect of niridazole [Ambilhar] on mice 1. Histopathological studies

ABSTRACT

The effect of ambilhar at different dose levels on normal non-infected as well as on Schistosoma-infected mice was studied. Histopathological examination showed the occurrence of degenerative and necrotic changes in the epithelial lining of the seminiferous tubules and inhibition of spermatogenesis in the tests at the dose range of 40 to 100 mg per kg body weight daily for a week. The interstitial cells were not affected. The changes in the tests were associated with manifestations of acute toxicity in mice treated with 40 mg. Changes in the liver were characterized by degenerative changes in the hepatic cells and mononuclear cell infiltrations in the portal tract. Changes related to toxicity were also seen in the kidney, heart, spleen and brain