Effect of splenectomy on s mansoni infestation and Microscopical picture of liver and lung in mice

ABSTRACT

The effect of splenectomy on S. mansoni infestation [worm burden, incubation period and pathology of liver and lung] was studied in two groups of mice, each of 40 mice. The first was splenectomized infested group and the second was control infested one. Histopathology of liver and lung was noticed at 50, 100 and 150 days post-infestation. The results showed that the prepatent period was significantly decreased from 44-45 days post infestation in the control group to 37-38 days in the splenectomized one. The number of worm burden was also affected by splenectomy. The histopathological changes of liver and lung in splenectomized mice was more aggressive than in control intact animals. The bilharzial tubercles increased in number, the hepatic tissue showed coagulative necrosis and the pathological changes in the lung appeared earlier and egg tubercles were also increased