Effect of somatostatin hormone analogue on intestinal motor activity

ABSTRACT

The effect of somatostatin hormone analogue, octreotide, on intestinal motor activity were studied using isolated segments from ileum and colon of rabbit. They were suspended in organ bath containing Tyrode's solution of PH 7.4 at 37C and bubbled with air. Motility was recorded using isotonic transducer and an ossilograph. It was found that octreotide was not acting by stimulation of either alpha or beta adrenergic receptors or by blocking muscarinic or hiatamine receptors or by increasing cyclic guanosine monophosphate [cGMP]. But octreotide may act by decreasing cyclic adinosine monophosphate [cAMP] and calcium influx from the extracellular fluid. This inhibitory effect of octreotide on colonic motility is one of its beneficial effects in treatment of persistent diarrheas