Octreotide infusion plus emergency sclerotherapy versus sclerotherapy alone for the control of bleeding oesophageal varices: a prospective randomized clinical trial

ABSTRACT

In a prospective trial, 189 patients with acute variceal bleeding were underwent emergency sclerotherapy of them, 93 patients were randomly assigned to receive a continuous infusion of octreotide [25 microgram per hour] for 5 days [group II]. The rest of patients [96 patients] treated with only sclerotherapy [group I]. After 7 days of follow up, the proportion of patients who had survived without re-bleeding was higher in group II patients who treated with both urgently sclerotherapy and octreotide [89 of 93 patients or 95.7%] than in patients treated with emergency sclerotherapy alone [group I]. The mean number of units of blood transfused was lower in group II than in group I. Also, bleeding was controlled rapidly in group II [2.26 +/- 0.8 days] versus group II [2.84 +/- 0.84 days]