Hepatoprotective effect of vitamins C and E on paracetamol toxicity in rats

ABSTRACT

It has been reported that the reactive metabolites of paracetamol is responsible for initiating liver cell injury. Furthermore, the involvement of free radicals and lipid peroxidation in the pathogenesis of reversible liver injury by various xenobiotics including paracetamol has been postulated for several years in animal models. The cytoprotective effects of currently used antioxidants, vitamin E and vitamin C, against various types of hepatotoxicity have been reported in previous studies. A model of paracetamol-induced hepatotoxicity was used in this study to investigate the possible prophylactic hepatoprotective role of vitamin E and/or vitamin C and their possible mechanism of protection