Idiopathic hyperammonemia after chemotherapy with vinorelbine, topotecan, and cisplatin in a patient with acute lymphocytic leukemia
Hematology, Oncology and Stem Cell Therapy. 2010; 3 (4): 199-202
en Inglés
| IMEMR
| ID: emr-108576
ABSTRACT
Idiopathic hyperammonemia [IHA] had been reported in some patients with hematological malignancy after receiving intensive chemotherapy, following bone marrow transplantation, or after using 5-fluorouracil for some solid tumors. The chemotherapeutic agents involved include cytarabine, daunomycin, cyclophosphamide, vincristine, amsacrine, etoposide, asparaginase, busulfan, and methotraxate, all used for treating hematological malignancies. No previous reports have described the association between idiopathic hyperammonemia and combined chemotherapy with vinorelbine, topotecan, and cisplatin. We describe a 20-year-old girl with normal liver function and relapsed precursor B-lymphoblastic leukemia receiving the modified TVTG [topotecan, vinorelbine, thiotepa, dexamethasone, and gemcitabine] protocol to control her disease. We used cisplatin [30 mg/m[2]/day] to replace thiotepa on day 3 because thiotepa was not available in Taiwan. The patient developed acute idiopathic hyperammonemia after 5 days of chemotherapy and died 9 days after chemotherapy. To our knowledge, this patient is the first report of the association of hyperammonemia and chemotherapy with vinorelbine, topotecan, and cisplatin in the English literature
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Vinblastina
/
Dexametasona
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Cisplatino
/
Tiotepa
/
Topotecan
/
Quimioterapia Combinada
Tipo de estudio:
Informe de Casos
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Hematol. Oncol. Stem Cell Ther.
Año:
2010
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